A cellular view of Nf2 in liver homeostasis and tumorigenesis

Dev Cell. 2010 Sep 14;19(3):363-4. doi: 10.1016/j.devcel.2010.08.015.


How liver adjusts and stabilizes its size is unsolved so far; the answers to this question may also provide insights into mechanisms of hepatocarcinogenesis. Two recent papers suggest a role for Merlin/Nf2 in control of liver cell turnover, but results appear conflicting at first glance.

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