Abstract
We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose:D-galactose:D-glucose:D-xylose:uronic acid:sulfate=1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-α, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.
MeSH terms
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Adjuvants, Immunologic
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Animals
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Antineoplastic Agents
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Cell Line
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Interleukin-6 / biosynthesis
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Laminaria / chemistry*
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Macrophage Activation / drug effects*
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Macrophages / cytology
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Macrophages / metabolism
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Mice
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Nitric Oxide / biosynthesis
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Phaeophyceae
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Adjuvants, Immunologic
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Antineoplastic Agents
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Interleukin-6
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Polysaccharides
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Tumor Necrosis Factor-alpha
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Nitric Oxide
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fucoidan