Fucoidan isolated from Laminaria angustata var. longissima induced macrophage activation

Biosci Biotechnol Biochem. 2010;74(9):1960-2. doi: 10.1271/bbb.100294. Epub 2010 Sep 7.

Abstract

We investigated macrophage activation by fucoidan from Laminaria angustata var. longissima in a murine macrophage cell line, RAW 264.7. The ratio of the chemical composition of the fucoidan was L-fucose:D-galactose:D-glucose:D-xylose:uronic acid:sulfate=1.00:0.54:0.08:0.08:0.64:0.87. The fucoidan induced production of nitric oxide, tumor necrosis factor-α, and interleukin-6 in RAW 264.7 cells. These results indicate that the fucoidan induced macrophage activation.

MeSH terms

  • Adjuvants, Immunologic
  • Animals
  • Antineoplastic Agents
  • Cell Line
  • Interleukin-6 / biosynthesis
  • Laminaria / chemistry*
  • Macrophage Activation / drug effects*
  • Macrophages / cytology
  • Macrophages / metabolism
  • Mice
  • Nitric Oxide / biosynthesis
  • Phaeophyceae
  • Polysaccharides / isolation & purification
  • Polysaccharides / pharmacology*
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Adjuvants, Immunologic
  • Antineoplastic Agents
  • Interleukin-6
  • Polysaccharides
  • Tumor Necrosis Factor-alpha
  • Nitric Oxide
  • fucoidan