Oxygen homeostasis

Wiley Interdiscip Rev Syst Biol Med. May-Jun 2010;2(3):336-361. doi: 10.1002/wsbm.69.


Metazoan life is dependent upon the utilization of O(2) for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Homeostasis / physiology*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / physiology*
  • Models, Biological*
  • Oxygen / metabolism*
  • Oxygen Consumption / physiology*
  • Signal Transduction / physiology*


  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Oxygen