Lipid and polymeric carrier-mediated nucleic acid delivery

Expert Opin Drug Deliv. 2010 Oct;7(10):1209-26. doi: 10.1517/17425247.2010.513969.

Abstract

Importance of the field: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined.

Areas covered in this review: The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations.

What the reader will gain: This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery.

Take home message: A thorough understanding of biological barriers and the structure-activity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • DNA
  • Drug Carriers / metabolism
  • Drug Carriers / pharmacology*
  • Drug Delivery Systems
  • Drug Design
  • Lipids / administration & dosage*
  • Lipids / chemistry
  • Molecular Targeted Therapy
  • Nucleic Acids / chemistry
  • Nucleic Acids / pharmacology*
  • Oligonucleotides, Antisense
  • Plasmids
  • Polymers / administration & dosage*
  • Polymers / chemistry
  • Structure-Activity Relationship

Substances

  • Drug Carriers
  • Lipids
  • Nucleic Acids
  • Oligonucleotides, Antisense
  • Polymers
  • DNA