Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)

Fitoterapia. 2011 Jan;82(1):38-43. doi: 10.1016/j.fitote.2010.09.004. Epub 2010 Sep 15.

Abstract

Ginger roots have been used to treat inflammation and have been reported to inhibit cyclooxygenase (COX). Ultrafiltration liquid chromatography mass spectrometry was used to screen a chloroform partition of a methanol extract of ginger roots for COX-2 ligands, and 10-gingerol, 12-gingerol, 8-shogaol, 10-shogaol, 6-gingerdione, 8-gingerdione, 10-gingerdione, 6-dehydro-10-gingerol, 6-paradol, and 8-paradol bound to the enzyme active site. Purified 10-gingerol, 8-shogaol and 10-shogaol inhibited COX-2 with IC(50) values of 32 μM, 17.5 μM and 7.5 μM, respectively. No inhibition of COX-1 was detected. Therefore, 10-gingerol, 8-shogaol and 10-shogaol inhibit COX-2 but not COX-1, which can explain, in part, the anti-inflammatory properties of ginger.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Catechols / chemistry
  • Catechols / isolation & purification
  • Catechols / pharmacology*
  • Chromatography, Liquid
  • Cyclooxygenase 2 Inhibitors / chemistry
  • Cyclooxygenase 2 Inhibitors / isolation & purification*
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / isolation & purification
  • Fatty Alcohols / pharmacology*
  • Ginger / chemistry*
  • Mass Spectrometry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Roots

Substances

  • Catechols
  • Cyclooxygenase 2 Inhibitors
  • Fatty Alcohols
  • Plant Extracts
  • gingerol