Irritable bowel syndrome and small intestinal bacterial overgrowth

J Clin Gastroenterol. 2010 Nov-Dec;44(10):672-5. doi: 10.1097/MCG.0b013e3181ef3476.


In the last 3 decades, there has been a growing appreciation for the role of gut bacteria in gastrointestinal disease. Although inflammatory bowel disease and peptic ulcer disease have established a role for gut bacteria for more than 20 years, there is now increasing evidence that intestinal bacteria may play a role in irritable bowel syndrome as well. In this review, the current evidence for bacteria in irritable bowel syndrome will be examined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Evidence-Based Medicine
  • Gastrointestinal Agents / therapeutic use
  • Humans
  • Intestine, Small / drug effects
  • Intestine, Small / microbiology*
  • Irritable Bowel Syndrome / diagnosis
  • Irritable Bowel Syndrome / drug therapy
  • Irritable Bowel Syndrome / microbiology*
  • Risk Assessment
  • Risk Factors
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Gastrointestinal Agents