Effects of mulberry leaf extract rich in 1-deoxynojirimycin on blood lipid profiles in humans

J Clin Biochem Nutr. 2010 Sep;47(2):155-61. doi: 10.3164/jcbn.10-53. Epub 2010 Aug 6.


Mulberry leaves are rich in 1-deoxynojirimycin (DNJ), an inhibitor of α-glucosidase. We previously showed that DNJ-rich mulberry leaf extract suppressed elevation of postprandial blood glucose in humans. The objective of this study was to evaluate the effects of DNJ-rich mulberry leaf extract on plasma lipid profiles in humans. An open-label, single-group study was conducted in 10 subjects with initial serum triglyceride (TG) level ≥200 mg/dl. Subjects ingested capsules containing DNJ-rich mulberry leaf extract at 12 mg three times daily before meals for 12 weeks. Our findings showed a modest decrease in serum TG level and beneficial changes in the lipoprotein profile following 12-week administration of DNJ-rich mulberry leaf extract. No significant changes in hematological or biochemical parameters were observed during the study period; no adverse events associated with DNJ-rich mulberry leaf extract occurred.

Keywords: 1-deoxynojirimycin; mulberry leaf extract; serum lipid profile; serum triglyceride.