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Review
. 2010 Nov;39(11):4114-29.
doi: 10.1039/c0cs00007h. Epub 2010 Sep 14.

Recent Advances in the Use of Temporary Silicon Tethers in Metal-Mediated Reactions

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Review

Recent Advances in the Use of Temporary Silicon Tethers in Metal-Mediated Reactions

Sonia Bracegirdle et al. Chem Soc Rev. .

Abstract

This tutorial review describes the use of temporary silicon tethers in metal-mediated organic reactions, a strategy which although well-established in traditional organic synthesis is still a blossoming field in the organometallic arena. The benefits of silicon-tethering are manifold: the reactivity, selectivity, and efficiency of organometallic processes can all be dramatically enhanced, often with unique regio- and stereochemical outcomes compared to the analogous intermolecular transformations. In addition, the residual silicon functionality can undergo a wide range of chemistry subsequent to the tethered reaction, creating further synthetic opportunities.

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