Aberrant signaling pathways in meningiomas

J Neurooncol. 2010 Sep;99(3):315-24. doi: 10.1007/s11060-010-0381-8. Epub 2010 Sep 14.


In this article, we provide a brief description of the current understanding of aberrant signaling pathways in meningiomas. Cell signaling pathways are responsible for cellular differentiation, development, growth, growth inhibition, and death. In fact, signaling pathways can affect multiple intracellular functions, including those responsible for development, angiogenesis, and apoptosis. Ultimately, a further understanding of the signaling pathways involved in meningioma tumorigenesis will lead to the development and application of novel molecular treatments, such as small molecule inhibitors or interfering ribonucleic acid technologies.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Meningeal Neoplasms / metabolism*
  • Meningeal Neoplasms / pathology
  • Meningioma / metabolism*
  • Meningioma / pathology
  • Signal Transduction*