Antiviral activity of Bignoniaceae species occurring in the State of Minas Gerais (Brazil): part 1

Lett Appl Microbiol. 2010 Oct;51(4):469-76. doi: 10.1111/j.1472-765X.2010.02924.x.

Abstract

Aims: To evaluate the antiviral activity of Bignoniaceae species occurring in the state of Minas Gerais, Brazil.

Methods and results: Ethanol extracts of different anatomical parts of bignoniaceous plant species have been evaluated in vitro against human herpesvirus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 34 extracts from 18 plant species selected according to ethnopharmacological and taxonomic criteria were screened. Fifteen of the 34 extracts (44.1%) have disclosed antiviral activity against one or more of the viruses assayed with EC(50) values in the range of 23.2 ± 2.5-422.7 ± 10.9 μg ml(-1).

Conclusions: Twelve of the 34 extracts (35.3%) might be considered promising sources of antiviral natural products, as they have shown EC50 ≤ 100 μg ml(-1). The present screening discloses the high potential of the Bignoniaceae family as source of antiviral agents.

Significance and impact of the study: Active extracts were identified and deserve bioguided studies for the isolation of antiviral compounds and studies on mechanism of action.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Bignoniaceae / chemistry*
  • Bignoniaceae / classification
  • Brazil
  • Chlorocebus aethiops
  • Encephalomyocarditis virus / drug effects*
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • L Cells
  • Mice
  • Microbial Sensitivity Tests / methods
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Vaccinia virus / drug effects*
  • Vero Cells

Substances

  • Antiviral Agents
  • Plant Extracts