Proteoglycans in health and disease: the multiple roles of syndecan shedding

FEBS J. 2010 Oct;277(19):3876-89. doi: 10.1111/j.1742-4658.2010.07798.x. Epub 2010 Aug 31.


Proteolytic processes in the extracellular matrix are a major influence on cell adhesion, migration, survival, differentiation and proliferation. The syndecan cell-surface proteoglycans are important mediators of cell spreading on extracellular matrix and respond to growth factors and other biologically active polypeptides. The ectodomain of each syndecan is constitutively shed from many cultured cells, but is accelerated in response to wound healing and diverse pathophysiological events. Ectodomain shedding is an important regulatory mechanism, because it rapidly changes surface receptor dynamics and generates soluble ectodomains that can function as paracrine or autocrine effectors, or competitive inhibitors. It is known that the family of syndecans can be shed by a variety of matrix proteinase, including many metzincins. Shedding is particularly active in proliferating and invasive cells, such as cancer cells, where cell-surface components are continually released. Here, recent research into the shedding of syndecans and its physiological relevance are assessed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Movement
  • Disease Progression
  • Glucuronidase / metabolism
  • Humans
  • Mammals
  • Matrix Metalloproteinases / metabolism
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • Proteoglycans / physiology*
  • Reference Values
  • Syndecans / metabolism
  • Syndecans / physiology*
  • Tissue Inhibitor of Metalloproteinases / metabolism
  • Wound Healing / physiology*


  • Proteoglycans
  • Syndecans
  • Tissue Inhibitor of Metalloproteinases
  • heparanase
  • Glucuronidase
  • Matrix Metalloproteinases