We report a case of a 76-year-old female with chronic back pain owing to a degenerative disc disease at L5 to S1. She underwent a paramedian lumbar interlaminar injection in the prone position at the level of L5-S1 using loss of resistance technique and without fluoroscopic guidance. The patient was admitted to the intensive care unit on the day after the procedure with objective signs of meningeal irritation. A computed tomography scan of the spine showed presence of multiple air levels within the spinal canal. The patient's symptoms resolved spontaneously and she was discharged to home the next day.