Pathways of mammalian replication fork restart

Nat Rev Mol Cell Biol. 2010 Oct;11(10):683-7. doi: 10.1038/nrm2974. Epub 2010 Sep 15.


Single-molecule analyses of DNA replication have greatly advanced our understanding of mammalian replication restart. Several proteins that are not part of the core replication machinery promote the efficient restart of replication forks that have been stalled by replication inhibitors, suggesting that bona fide fork restart pathways exist in mammalian cells. Different models of replication fork restart can be envisaged, based on the involvement of DNA helicases, nucleases, homologous recombination factors and the importance of DNA double-strand break formation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bloom Syndrome / genetics
  • DNA / genetics*
  • DNA Damage
  • DNA Helicases / genetics
  • DNA Helicases / metabolism
  • DNA Replication*
  • DNA, Cruciform / genetics
  • Humans
  • Mammals
  • Models, Genetic


  • DNA, Cruciform
  • DNA
  • DNA Helicases