Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung disease

Int J Med Microbiol. 2010 Dec;300(8):514-9. doi: 10.1016/j.ijmm.2010.08.002. Epub 2010 Sep 16.


One of the first pathogens which can be isolated from the airways of cystic fibrosis (CF) patients is Staphylococcus aureus, which often persists in this hostile environment for many months or even years. The increase in infections due to the methicillin-resistant S. aureus (MRSA) worldwide and even more the emergence of community-acquired MRSA, which differ from nosocomial MRSA by lack of multiresistance and carriage of a phage-encoded toxin, Panton-Valentine leukocidin, attracts new attention to the epidemiology, pathogenesis, and impact of S. aureus in the background of CF. In this review, recent data and studies will be reported and discussed to give an overview of the latest research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / pathology
  • Cystic Fibrosis / complications*
  • Humans
  • Pneumonia, Staphylococcal / epidemiology*
  • Pneumonia, Staphylococcal / microbiology
  • Pneumonia, Staphylococcal / pathology*
  • Prevalence
  • Staphylococcus aureus / isolation & purification*
  • Staphylococcus aureus / pathogenicity*