Streptococcus pneumoniae nasopharyngeal colonization in children in Brasov, Central Romania: high antibiotic resistance and coverage by conjugate vaccines

Pediatr Infect Dis J. 2011 Jan;30(1):76-8. doi: 10.1097/INF.0b013e3181f42bb6.

Abstract

We report high colonization rates among 400 healthy infants and children, and moderate (66%) coverage by PCV7 and PCV10, with a superior (80%) PCV13 coverage. Most frequent serotypes were 23F, 6B, 19F, and 14. Resistance to penicillin, ceftriaxone, erythromycin, and trimethoprim/sulfamethoxazole was 83%, 18%, 62%, and 66%, respectively. 67% isolates were multidrug resistant. Pneumococcal conjugate vaccines covered 80% to 93% of multidrug resistant isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carrier State / epidemiology*
  • Carrier State / microbiology
  • Child, Preschool
  • Drug Resistance, Bacterial
  • Humans
  • Infant
  • Microbial Sensitivity Tests
  • Nasopharynx / microbiology*
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / prevention & control
  • Romania / epidemiology
  • Serotyping
  • Streptococcal Vaccines / administration & dosage*
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / isolation & purification*
  • Vaccines, Conjugate / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Streptococcal Vaccines
  • Vaccines, Conjugate