From Saccharomyces cerevisiae to Candida glabratain a few easy steps: important adaptations for an opportunistic pathogen

FEMS Microbiol Lett. 2011 Jan;314(1):1-9. doi: 10.1111/j.1574-6968.2010.02102.x. Epub 2010 Sep 16.


The opportunistic human fungal pathogen Candida glabrata is closely related to Saccharomyces cerevisiae, yet it has evolved to survive within mammalian hosts. Which traits help C. glabrata to adapt to this different environment? Which specific responses are crucial for its survival in the host? The main differences seem to include an extended repertoire of adhesin genes, high drug resistance, an enhanced ability to sustain prolonged starvation and adaptations of the transcriptional wiring of key stress response genes. Here, we discuss the properties of C. glabrata with a focus on the differences to related fungi.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Candida glabrata / classification
  • Candida glabrata / genetics
  • Candida glabrata / pathogenicity*
  • Candida glabrata / physiology*
  • Candidiasis / microbiology*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal
  • Humans
  • Phylogeny
  • Saccharomyces cerevisiae / classification
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*


  • Fungal Proteins