Sickle cell trait and stroke in the young adult

Postgrad Med J. 1990 Dec;66(782):1078-80. doi: 10.1136/pgmj.66.782.1078.


Two young patients with sickle cell trait (AS haemaglobinopathy) and ischaemic stroke are reported. The stroke involved the internal carotid artery territory in one and the brainstem in the other. A review of the literature is presented to suggest that the association of sickle cell trait and cerebral infarction is more than coincidental. Haemoglobin electrophoresis should be undertaken routinely in young subjects with ischaemic stroke.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Carotid Artery Thrombosis / etiology
  • Carotid Artery, Internal
  • Cerebral Infarction / etiology*
  • Female
  • Humans
  • Male
  • Pons / blood supply
  • Sickle Cell Trait / complications*