Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 48 (3), 357-69

Genetic Heterogeneity of the Human Glutathione Transferases: A Complex of Gene Families

Affiliations
Review

Genetic Heterogeneity of the Human Glutathione Transferases: A Complex of Gene Families

P Board et al. Pharmacol Ther.

Abstract

The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationships between the various isoenzymes, their deficiencies and the physical locations of their genes.

Similar articles

See all similar articles

Cited by 52 articles

See all "Cited by" articles

LinkOut - more resources

Feedback