Put them out to pasture? What are old granule cells good for, anyway...?

Hippocampus. 2010 Oct;20(10):1124-5. doi: 10.1002/hipo.20867.

Abstract

In this issue, Alme and colleagues propose a novel hypothesis that young adult-born neurons represent the functional population of the dentate gyrus, and that old granule cells "retire" from relevance. Here, we present several implications of this interesting theory for the function of both neurogenesis and the dentate gyrus.

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Dentate Gyrus / cytology*
  • Dentate Gyrus / physiology*
  • Humans
  • Learning / physiology*
  • Memory / physiology*
  • Models, Neurological
  • Nerve Net / cytology
  • Nerve Net / physiology
  • Neural Pathways / cytology
  • Neural Pathways / physiology
  • Neurogenesis / physiology*
  • Neuronal Plasticity / physiology
  • Neurons / physiology*