Latent herpes simplex virus in ganglia of mice after primary infection and reinoculation at a distant site

Arch Virol. 1978;57(2):161-6. doi: 10.1007/BF01315677.


Herpes simplex virus (HSV)-infected hairless mice with evidence of latent infection in spinal ganglia did not develop latent HSV infections in trigeminal ganglia upon reinfection in the oro-facial area. HSV-infected and PAA-treated mice without evidence of latent HSV infection in spinal ganglia were resistant to reinfection in the lumbar region, but not to that performed in the oro-facial area.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Central Nervous System Diseases / immunology
  • Ganglia*
  • Ganglia, Spinal*
  • Herpes Simplex / immunology*
  • Immunity
  • Mice
  • Mice, Nude
  • Phosphonoacetic Acid / pharmacology
  • Simplexvirus / immunology


  • Antibodies, Viral
  • Phosphonoacetic Acid