PARP around the clock

Cell. 2010 Sep 17;142(6):841-3. doi: 10.1016/j.cell.2010.08.037.

Abstract

Cells possess internal ∼24 hr or circadian clocks that synchronize physiological processes with daily cycles of light and nutrient availability. In this issue, Asher et al. (2010) find that PARP-1 (poly(ADP-ribose) polymerase 1) modifies components of the clock machinery in response to feeding, providing a mechanism for how metabolic rhythms coordinate with circadian rhythms.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't