Abstract
The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H-(substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram +ve), Escherichia coli, Pseudomonas aeruginosa (gram -ve) and antifungal activity against Aspergillus niger and anticancer activity (HL-60, Hep-2 & HEK293T) by MTT assay. Chloro substituted compounds showed antimicrobial and anticancer activity with IC(50) values in the low micromolar range.
Copyright © 2010. Published by Elsevier Ltd.
MeSH terms
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Acridines / chemical synthesis*
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Acridines / pharmacology*
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Aspergillus niger / drug effects
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Bacteria / drug effects
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Spectrophotometry, Infrared
Substances
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Acridines
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents
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Indicators and Reagents