Distance delivery of mindfulness-based cognitive therapy for depression: project UPLIFT

Epilepsy Behav. 2010 Nov;19(3):247-54. doi: 10.1016/j.yebeh.2010.07.031. Epub 2010 Sep 20.


This study evaluated the efficacy of a newly developed, home-based depression intervention for people with epilepsy. Based on mindfulness-based cognitive therapy (MBCT), the eight-session, weekly intervention was designed for group delivery via the Internet or telephone. Forty participants were randomly assigned to intervention or waitlist. Depressive symptoms and other outcomes were measured at baseline, after intervening in the intervention group (~8 weeks), and after intervening in the waitlist group (~16 weeks). Depressive symptoms decreased significantly more in the intervention group than the waitlist group; Internet and telephone did not differ. This effect persisted over the 8 weeks when those waitlisted received the intervention. Knowledge/skills increased significantly more in the intervention than the waitlist group. All other changes, though not significant, were in the expected direction. Findings indicate that distance delivery of group MBCT can be effective in reducing symptoms of depression in people with epilepsy. Directions for future research are proposed.

Publication types

  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Child
  • Child, Preschool
  • Cognitive Behavioral Therapy / methods*
  • Cross-Over Studies
  • Delivery of Health Care / methods*
  • Depression / etiology
  • Depression / rehabilitation*
  • Epilepsy / complications
  • Female
  • Humans
  • Internet
  • Male
  • Meditation / methods*
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Psychotherapy, Group / methods*
  • Quality of Life
  • Retrospective Studies
  • Self Efficacy
  • Surveys and Questionnaires
  • Treatment Outcome
  • Young Adult