[Diabetes and Hypokinetic Cardiopathy : When to Consider Mitochondrial Disease?]

Ann Cardiol Angeiol (Paris). 2011 Jun;60(3):176-8. doi: 10.1016/j.ancard.2010.08.003. Epub 2010 Aug 26.
[Article in French]

Abstract

The association between diabetes mellitus and hypokinetic cardiomyopathy is frequent. We report a case of diabetes and hypokinetic cardiopathy in a 40-year-old man which led to the hypothesis of maternally inherited diabetes and deafness (MIDD) due to a mitochondrial disease. This diagnosis was confirmed by genetic testing which showed a DNA A3243G mutation in the mitochondria, the prevalence of which is 1-2% in diabetes mellitus. Cardiac abnormalities are frequent (18-34% of patients depending on the series) and the co-existence of left ventricular hypertrophy and systolic dysfunction is suggestive of this disease. Some authors have proposed co-enzyme Q as a treatment to improve the left ventricular ejection fraction and insulin secretion.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Cardiomyopathy, Dilated / diagnosis*
  • Cardiomyopathy, Dilated / genetics
  • DNA Mutational Analysis
  • DNA, Mitochondrial / genetics
  • Deafness / diagnosis
  • Deafness / genetics
  • Diabetes Mellitus / diagnosis*
  • Diabetes Mellitus / genetics*
  • Diagnosis, Differential
  • Echocardiography
  • Genes, Mitochondrial / genetics
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Mitochondrial Diseases / diagnosis*
  • Mitochondrial Diseases / genetics
  • Syndrome

Substances

  • DNA, Mitochondrial

Supplementary concepts

  • Familial dilated cardiomyopathy