Recurrent seizure-related injuries in people with epilepsy at a tertiary epilepsy center: a 2-year longitudinal study

Epilepsy Behav. 2010 Nov;19(3):400-4. doi: 10.1016/j.yebeh.2010.07.029. Epub 2010 Sep 18.


Though seizure-related injuries (SRIs) among people with epilepsy (PWE) have recently gained much attention in the literature, most studies are retrospective and data are gathered indirectly through questionnaires or medical record documentation. We investigated SRIs and their associated risks in PWE attending a tertiary care center with direct and systematic inquiries during routine clinic follow-up visits over a 2-year period (N = 306). Past SRIs occurred in 54% of all patients, and 24% experienced recurrent SRIs during the study period. On multiple regression analyses, past SRI was associated with tonic-clonic seizures (TCSs) (3.2, 95% CI = 1.7-5.8) and cognitive handicap (4.3, 95% CI 1.5-16.1), and recurrent SRI was associated with TCSs (3.5, 95% CI = 1.6-7.9). Most recurrent SRIs (72%) involved head injury. SRIs are common when assessed systematically in a tertiary care setting, and TCSs represent a risk factor for recurrent SRIs. The potential clinical impact of recurrent SRIs on PWE requires further study.

MeSH terms

  • Adult
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Recurrence
  • Risk Factors
  • Seizures / complications*
  • Seizures / epidemiology
  • Wounds and Injuries / classification
  • Wounds and Injuries / epidemiology*
  • Wounds and Injuries / etiology*