From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets

Eur J Immunol. 2010 Aug;40(8):2089-94. doi: 10.1002/eji.201040498.


Recent studies have identified several DC subsets within the mouse skin and showed that functional specialization exists among them. This Viewpoint summarizes recent data on functional specialization of skin DC subsets and integrates this knowledge into a unifying DC classification that emphasizes the similarities between the DC subsets found in both lymphoid and nonlymphoid tissues of several mammalian species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Cell Movement
  • Humans
  • Langerhans Cells / classification*
  • Langerhans Cells / pathology
  • Lymphoid Tissue / pathology*
  • Mice
  • Skin / pathology*