Abstract
The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcysteine / pharmacology
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Animals
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Antioxidants / pharmacology
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Flavones / chemistry
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Flavones / pharmacology
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Hindlimb Suspension
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Lipid Peroxidation / drug effects
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Male
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Mice
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Mice, Inbred C57BL
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Molecular Structure
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Muscle, Skeletal / drug effects
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Muscular Atrophy / drug therapy*
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Polymerase Chain Reaction
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Propane / analogs & derivatives
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Propane / pharmacology
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Quercetin / chemistry
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Quercetin / pharmacology*
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Thiobarbituric Acid Reactive Substances / analysis
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Ubiquitin-Protein Ligases / drug effects*
Substances
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Antioxidants
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Flavones
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Thiobarbituric Acid Reactive Substances
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1,1,3,3-tetraethoxypropane
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Quercetin
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Ubiquitin-Protein Ligases
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Propane
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Acetylcysteine