A call for action: Comparative effectiveness research in asthma

doi:10.1016/j.jaci.2010.08.032

Review

. 2011 Jan;127(1):123-7.

doi: 10.1016/j.jaci.2010.08.032. Epub 2010 Sep 19.

A call for action: Comparative effectiveness research in asthma

Jerry A Krishnan¹, Michael Schatz, Andrea J Apter

Affiliations

PMID: 20855111
PMCID: PMC3017678
DOI: 10.1016/j.jaci.2010.08.032

Review

A call for action: Comparative effectiveness research in asthma

Jerry A Krishnan et al. J Allergy Clin Immunol. 2011 Jan.

. 2011 Jan;127(1):123-7.

doi: 10.1016/j.jaci.2010.08.032. Epub 2010 Sep 19.

Authors

Jerry A Krishnan¹, Michael Schatz, Andrea J Apter

Affiliation

¹ Department of Medicine, Section of Pulmonary and Critical Care, University of Chicago, Chicago, Ill. 60637, USA. jkrishna@medicine.bsd.uchicago.edu

PMID: 20855111
PMCID: PMC3017678
DOI: 10.1016/j.jaci.2010.08.032

Abstract

Comparative effectiveness research (CER) has received considerable research attention in recent months, and efforts to promote CER are part of the newly enacted Patient Protection and Affordable Care Act. In this article we define CER and how it complements traditional efficacy research in asthma and discuss how CER can help provide the basis for rational decision making about the care of individual patients with asthma and how best to deliver this care in real-world settings. We present information about the challenges and opportunities to conduct CER, including enhanced patient registries for observational CER and effectiveness trials (also called pragmatic trials). We discuss the urgent need to define the appropriate methodologies for CER and to develop and prioritize a research agenda for CER studies in asthmatic subjects with the help of a diverse group of stakeholders.

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References

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1. Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15;181(2):116–124. Epub 2009 Oct 8. - PMC - PubMed
1. Kiljander TO, Junghard O, Beckman O, Lind T. Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2010;181:1042–1048. - PubMed
1. Lemanske RF, Jr, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Covar RA, Guilbert TW, Larsen G, Morgan WJ, Moss MH, Spahn JD, Taussig LM. Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010;362:975–985. - PMC - PubMed

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[1] Travers J, Marsh S, Williams M, Weatherall M, Caldwell B, Shirtcliffe P, Aldington S, Beasley R. External validity of randomized controlled trials in asthma: to whom do the results of the trials apply? Thorax. 2007;62:219–223. - PMC - PubMed

[2] Travers J, Marsh S, Williams M, Weatherall M, Caldwell B, Shirtcliffe P, Aldington S, Beasley R. External validity of randomized controlled trials in asthma: to whom do the results of the trials apply? Thorax. 2007;62:219–223. - PMC - PubMed

[3] Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI), Clinical Centers for the NHLBI Asthma Network (AsthmaNet) (U10), RFA-HL-08-010. [accessed July 13, 2010]. http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-08-010.html.

[4] Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI), Clinical Centers for the NHLBI Asthma Network (AsthmaNet) (U10), RFA-HL-08-010. [accessed July 13, 2010]. http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-08-010.html.

[5] Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15;181(2):116–124. Epub 2009 Oct 8. - PMC - PubMed

[6] Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010 Jan 15;181(2):116–124. Epub 2009 Oct 8. - PMC - PubMed

[7] Kiljander TO, Junghard O, Beckman O, Lind T. Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2010;181:1042–1048. - PubMed

[8] Kiljander TO, Junghard O, Beckman O, Lind T. Effect of esomeprazole 40 mg once or twice daily on asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2010;181:1042–1048. - PubMed

[9] Lemanske RF, Jr, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Covar RA, Guilbert TW, Larsen G, Morgan WJ, Moss MH, Spahn JD, Taussig LM. Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010;362:975–985. - PMC - PubMed

[10] Lemanske RF, Jr, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Covar RA, Guilbert TW, Larsen G, Morgan WJ, Moss MH, Spahn JD, Taussig LM. Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010;362:975–985. - PMC - PubMed

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A call for action: Comparative effectiveness research in asthma

Affiliation

A call for action: Comparative effectiveness research in asthma

Authors

Affiliation

Abstract

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Cited by

References

Publication types

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Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous