Surgical outcomes after massive subretinal hemorrhage secondary to age-related macular degeneration

Retina. Nov-Dec 2010;30(10):1588-94. doi: 10.1097/IAE.0b013e3181e2263c.

Abstract

Purpose: Massive subretinal hemorrhage (SRH), defined as a thick submacular bleed that extends past the equator in at least two quadrants, is a rare sequela of age-related macular degeneration. This report describes outcomes after surgical intervention for massive SRH.

Methods: The study design is a retrospective interventional case series. Records of consecutive patients who underwent surgical intervention for massive SRH were reviewed. Outcomes included change from baseline in postoperative acuity at Months 1, 3, 6, 9, and 12 and postoperative complications.

Results: Fifteen consecutive eyes of 13 patients who underwent surgery for massive SRH were included. Procedures performed on initial surgery included subretinal instillation of 25 μg/0.1 mL tissue plasminogen activator (15 of 15), gas tamponade (12 of 15), oil tamponade (3 of 15), 180° or greater retinotomy (4 of 15), and/or cataract extraction (2 of 15). Patients were followed for a median of 20 months (range, 3-66 months). The median visual acuity at baseline and postoperative Month 1 was hand motions but improved to counting fingers at postoperative Months 3 (P = 0.04), 6 (P = 0.04), 9 (P = 0.04), and 12 (P = 0.10). Of the 15 eyes, 9 required at least 1 additional procedure for an indication of hyphema and/or vitreous hemorrhage (n = 6), retinal detachment (n = 2), glaucoma (n = 1), cataract (n = 1), and aphakia (n = 1). At the time of the onset of SRH, 5 of 13 patients were anticoagulated with warfarin (4 patients) or clopidogrel (1 patient), and 1 was diagnosed with a coagulopathy, factor XI deficiency.

Conclusion: Massive SRH related to age-related macular degeneration has a grave prognosis. Risk factors may include anticoagulation and coagulopathy. Limitations of the study include its retrospective nature, small sample size, imprecision in acuity measurements below 20/400, and lack of a control group. In this series, surgical intervention was associated with a modest improvement in median visual acuity up to 1 year postoperatively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Combined Modality Therapy
  • Female
  • Fluorocarbons / administration & dosage
  • Follow-Up Studies
  • Humans
  • Macular Degeneration / complications*
  • Macular Degeneration / physiopathology
  • Male
  • Postoperative Complications
  • Prone Position
  • Retinal Hemorrhage / etiology
  • Retinal Hemorrhage / physiopathology
  • Retinal Hemorrhage / surgery*
  • Retrospective Studies
  • Tissue Plasminogen Activator / administration & dosage*
  • Treatment Outcome
  • Visual Acuity / physiology
  • Vitrectomy*

Substances

  • Fluorocarbons
  • Tissue Plasminogen Activator