The Goldilocks model for TCR-too much attraction might not be best for vaccine design

PLoS Biol. 2010 Sep 14;8(9):e1000482. doi: 10.1371/journal.pbio.1000482.

Abstract

Recent research on T cell-antigen interactions suggests that tighter binding is not always better at eliciting an effective immune response.

MeSH terms

  • Models, Biological*
  • Mutation
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology*
  • Vaccines*

Substances

  • Receptors, Antigen, T-Cell
  • Vaccines