Abstract
Investigation of characteristic constituents of the roots of Glycyrrhiza uralensis Fischer led to isolation of four new triterpene glucuronides, namely uralsaponins C-F (1-4), an artificial product, namely the methyl ester of glycyrrhizin (5), as well as six known triterpene glucuronides (6-11). These new compounds were identified by 1D and 2D NMR spectroscopic analysis. The cytotoxicity of the selected compounds and their aglycones were evaluated against HeLa and MCF-7 cancer cell lines, and the preliminary structure-activity relationship was also elucidated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Breast Neoplasms / drug therapy
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Cell Line, Tumor
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Female
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Glycyrrhiza / chemistry*
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Glycyrrhizic Acid / isolation & purification
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Glycyrrhizic Acid / pharmacology
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Glycyrrhizic Acid / therapeutic use
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HeLa Cells
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Humans
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Molecular Structure
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Neoplasms / drug therapy*
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Phytotherapy
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Roots
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / therapeutic use*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Saponins
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Glycyrrhizic Acid