Decreased bone turnover in children and adolescents with well controlled type 1 diabetes

J Pediatr Endocrinol Metab. 2010 Jul;23(7):697-707. doi: 10.1515/jpem.2010.23.7.697.

Abstract

Aim: Osteoporosis is a common long-term complication of type 1 diabetes (T1DM). We aimed to determine whether bone mineral density (BMD) and turnover are already altered during childhood.

Patients and methods: We recruited 27 T1DM children and 32 controls (age 10.5 +/- 2.5 yr.) and measured BMD (dual-energy x-ray absorptiometry); bone biomarkers levels (osteocalcin: OC; procollagen type 1 propeptides amino-terminal: PINP; crosslinking telopeptides of type 1 collagen C-terminal: CTX), glycated hemoglobin (HbA1c), dietary intake and physical activity.

Results: Patients with T1DM had lower levels of OC (70.3 +/- 3.3 vs 105.3 +/- 6.8), PINP (556.4 +/- 47.6 vs 716.3 +/- 53.8), CTX(0.97 +/- 0.07 vs 1.20 +/- 0.08), physical activity, and calcium intake. Biomarkers were negatively correlated with HbA1c. Though, BMD was similar among groups and not related to HbA1c, disease duration, physical activity or dietary intakes.

Conclusions: Bone turnover is altered in T1DM children, whereas BMD remains normal during growth. Physical activity and optimal calcium intakes may improve bone metabolism and delay osteoporosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Bone Density
  • Bone Remodeling*
  • Child
  • Collagen Type I / blood
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / metabolism*
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Male
  • Osteocalcin / blood
  • Peptide Fragments / blood
  • Peptides / blood
  • Procollagen / blood

Substances

  • Collagen Type I
  • Glycated Hemoglobin A
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • hemoglobin A1c protein, human
  • procollagen Type I N-terminal peptide
  • Osteocalcin