Novel technologies to detect atelectotrauma in the injured lung

Exp Lung Res. 2011 Feb;37(1):18-25. doi: 10.3109/01902148.2010.501402. Epub 2010 Sep 23.


Cyclical recruitment and derecruitment of lung parenchyma (R/D) remains a serious problem in ALI/ARDS patients, defined as atelectotrauma. Detection of cyclical R/D to titrate the optimal respiratory settings is of high clinical importance. Image-based technologies that are capable of detecting changes of lung ventilation within a respiratory cycle include dynamic computed tomography (dCT), synchrotron radiation computed tomography (SRCT), and electrical impedance tomography (EIT). Time-dependent intra-arterial oxygen tension monitoring represents an alternative approach to detect cyclical R/D, as cyclical R/D can result in oscillations of PaO₂ within a respiratory cycle. Continuous, ultrafast, on-line in vivo measurement of PaO₂ can be provided by an indwelling PaO₂ probe. In addition, monitoring of fast changes in SaO₂ by pulse oximetry technology at the bedside could also be used to detect those fast changes in oxygenation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Lung Injury / diagnosis*
  • Acute Lung Injury / physiopathology
  • Acute Lung Injury / therapy
  • Diagnostic Imaging* / methods
  • Electric Impedance
  • Humans
  • Image Interpretation, Computer-Assisted
  • Oximetry*
  • Predictive Value of Tests
  • Prognosis
  • Respiration, Artificial
  • Respiratory Distress Syndrome / diagnosis*
  • Respiratory Distress Syndrome / physiopathology
  • Respiratory Distress Syndrome / therapy
  • Severity of Illness Index
  • Tomography, X-Ray Computed