A case of SRY-positive 38,XY true hermaphroditism (XY sex reversal) in a cat

Vet Pathol. 2011 Jul;48(4):817-22. doi: 10.1177/0300985810382093. Epub 2010 Sep 22.


Investigation of abnormal sexual development in companion animals can allow for the elimination of inherited disorders from breeding populations while contributing to the understanding of the complex process of mammalian sexual development and differentiation. A 1-year-old mixed-breed cat, presented for neutering, was tentatively diagnosed as a male with bilateral cryptorchidism. During surgery, the surgeon identified gonads in an ovarian position and a complete bicornuate uterus. Both testicular and ovarian architecture in the gonads and Mullerian and Wolffian duct derivatives were identified histologically. The karyotype was that of a normal male (38,XY), and no causative mutation was identified in the feline SRY coding sequence amplified from genomic DNA. All features of the case were compatible with a diagnosis of SRY-positive 38,XY sex reversal, true hermaphrodite phenotype. To the authors' knowledge, this is the first report of this disorder in a domestic cat.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cat Diseases / genetics
  • Cat Diseases / pathology*
  • Cat Diseases / surgery
  • Cats
  • Female
  • Gonads / pathology
  • Karyotyping
  • Male
  • Ovotesticular Disorders of Sex Development / genetics
  • Ovotesticular Disorders of Sex Development / pathology
  • Ovotesticular Disorders of Sex Development / surgery
  • Ovotesticular Disorders of Sex Development / veterinary*
  • Sex-Determining Region Y Protein / genetics*
  • Uterus / pathology


  • Sex-Determining Region Y Protein