Comment on "The origins of sexually transmitted HIV among men who have sex with men"

Sci Transl Med. 2010 Sep 22;2(50):50le1; author reply 50lr1. doi: 10.1126/scitranslmed.3001416.


Whether HIV from seminal cells or free HIV in semen is the origin of transmitted virus has important implications for the design of transmission prevention strategies. We found that a recent claim that HIV originates from seminal plasma and not from seminal cells was erroneous, because it was based on biological specimens that had been mislabeled, mixed-up, or contaminated. The origin of transmitted virus from semen therefore remains an open question.

Publication types

  • Comment
  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Disease
  • Adult
  • Cell Compartmentation
  • Chronic Disease
  • HIV Infections / transmission*
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • Homosexuality, Male*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / analysis
  • RNA, Viral / genetics
  • Semen / cytology
  • Semen / virology
  • Young Adult


  • RNA, Viral