Methacrylate monomers lower the level of reduced glutathione and increase the in vitro sensitivity of cells to optical radiation

Photochem Photobiol Sci. 2010 Dec;9(12):1597-600. doi: 10.1039/c0pp00240b. Epub 2010 Sep 23.

Abstract

Induction of cell death by optical radiation in the wavelength range 350-500 nm was significantly increased by commonly used methacrylate monomers, not mediated by absorption of radiation by the methacrylate monomers, but through a mechanism involving rapid reduction in the level of glutathione (GSH).

MeSH terms

  • Animals
  • Apoptosis
  • Cell Line
  • Glutathione / metabolism*
  • Methacrylates / chemistry*
  • Methacrylates / toxicity
  • Oxidation-Reduction
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / toxicity
  • Polymethacrylic Acids / chemistry
  • Polymethacrylic Acids / toxicity
  • Radiation*
  • Rats

Substances

  • Methacrylates
  • Polymethacrylic Acids
  • triethylene glycol dimethacrylate
  • Polyethylene Glycols
  • hydroxyethyl methacrylate
  • Glutathione