Outcomes after central grey matter injury in term perinatal hypoxic-ischaemic encephalopathy

Early Hum Dev. 2010 Nov;86(11):675-82. doi: 10.1016/j.earlhumdev.2010.08.013.


Central grey matter damage following perinatal hypoxia-ischaemia frequently leads to death or motor abnormality often with deficits in other developmental domains. Predicting these different outcomes is difficult yet very important for early management, planning and providing for needs on discharge and later and not least for parents to know how their children will be affected. The best single predictor of the pattern of outcomes for an individual infant is an early MRI scan. We present a guide for predicting outcome at 2 years in different developmental domains based on the severity of injury seen in the basal ganglia and thalami (BGT) on neonatal MRI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basal Ganglia Diseases / diagnosis
  • Basal Ganglia Diseases / etiology*
  • Cerebral Palsy / diagnosis
  • Cerebral Palsy / etiology
  • Child, Preschool
  • Comorbidity
  • Humans
  • Hypoxia-Ischemia, Brain / complications*
  • Hypoxia-Ischemia, Brain / diagnosis
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Survival Rate
  • Term Birth
  • Thalamic Diseases / diagnosis
  • Thalamic Diseases / etiology*