Enterohemorrhagic Escherichia coli O26:H11-Associated Hemolytic Uremic Syndrome: Bacteriology and Clinical Presentation

Semin Thromb Hemost. 2010 Sep;36(6):586-93. doi: 10.1055/s-0030-1262880. Epub 2010 Sep 23.


Infection by enterohemorrhagic ESCHERICHIA COLI (EHEC) is the most frequent cause of hemolytic uremic syndrome (HUS) in childhood. During a 6-year period, all patients with the clinical diagnosis of HUS were registered in a prospective multicenter study in Austria and Germany. EHEC O26:H11 was the second most frequent detected serotype, accounting for 15.4% of all EHEC isolates. The presence of EHEC O26:H11 was significantly associated with young age at the disease onset ( P < 0.001). Patients infected with this serotype were not different in their clinical presentation than those infected with other serotypes. This study underlines the importance of EHEC serotypes other than O157 in the etiology of HUS and emphasizes the importance of implementation of appropriate diagnostic methods to identify the whole spectrum of EHEC associated with HUS.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Austria
  • Child
  • Child, Preschool
  • Diarrhea / complications
  • Enterohemorrhagic Escherichia coli / classification
  • Enterohemorrhagic Escherichia coli / pathogenicity
  • Enterohemorrhagic Escherichia coli / physiology*
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / therapy
  • Escherichia coli O157 / genetics
  • Escherichia coli O157 / pathogenicity
  • Escherichia coli O157 / physiology
  • Female
  • Germany
  • Hemolytic-Uremic Syndrome / complications
  • Hemolytic-Uremic Syndrome / microbiology*
  • Hemolytic-Uremic Syndrome / therapy
  • Host-Pathogen Interactions
  • Humans
  • Hypertension / complications
  • Infant
  • Leukocyte Count
  • Male
  • Peritoneal Dialysis
  • Phylogeny
  • Platelet Count
  • Prospective Studies
  • Renal Dialysis
  • Shiga Toxin 2 / genetics
  • Species Specificity
  • Virulence


  • Shiga Toxin 2