Implementation of dynamic Bayesian decision making by intracellular kinetics

Phys Rev Lett. 2010 Jun 4;104(22):228104. doi: 10.1103/PhysRevLett.104.228104. Epub 2010 Jun 3.

Abstract

Decision making in a noisy and dynamically changing environment is a fundamental task for a cell. To choose appropriate decisions over time, a cell must be equipped with intracellular kinetics that can conduct dynamic and efficient decision making. By using the theory of sequential inference, I demonstrate that dynamic Bayesian decision making can be implemented by an intracellular kinetics with a dual positive feedback structure. I also show that the combination of linear instantaneous and nonlinear stationary sensitivities to the input dominantly contributes to decision making efficiency, and that the state-dependent sensitivity change further suppresses noisy response. The statistical principles underlying these two factors are further clarified to be a log-likelihood-dependent quantification of the input information and uncertainty-dependent sensitivity control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • Feedback, Physiological
  • Intracellular Space / metabolism*
  • Kinetics
  • Models, Biological*