We report a measurement of the ratio of the tt to Z/γ{*} production cross sections in sqrt[s]=1.96 TeV pp collisions using data corresponding to an integrated luminosity of up to 4.6 fb{-1}, collected by the CDF II detector. The tt cross section ratio is measured using two complementary methods, a b-jet tagging measurement and a topological approach. By multiplying the ratios by the well-known theoretical Z/γ{*}→ll cross section predicted by the standard model, the extracted tt cross sections are effectively insensitive to the uncertainty on luminosity. A best linear unbiased estimate is used to combine both measurements with the result σ{tt}=7.70±0.52 pb, for a top-quark mass of 172.5 GeV/c{2}.