PolyQ disease: too many Qs, too much function?

Neuron. 2010 Sep 23;67(6):897-9. doi: 10.1016/j.neuron.2010.09.012.


The nature of the gain-of-function toxicity found in polyglutamine (polyQ) diseases has been the subject of considerable debate. In this issue of Neuron, Duvick et al. and Nedelsky et al. show that, in two of these diseases, pathology is mediated by normal protein activity.

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