Gd-EOB-DTPA enhanced MR imaging: evaluation of biliary and renal excretion in normal and cirrhotic livers

Eur J Radiol. 2011 Dec;80(3):e207-11. doi: 10.1016/j.ejrad.2010.08.033. Epub 2010 Sep 24.


Objective: The purpose of this study was to assess the difference in the activity of biliary and renal excretion between normal and cirrhotic livers on contrast-enhanced MR imaging obtained with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA).

Methods: A total of 78 patients with cirrhotic liver (n=44) and with normal liver (n=34) underwent multi-phase Gd-EOB-DTPA enhanced MR imaging (arterial, portal, equilibrium, and three hepatobiliary phases (10, 15 and 20 min HP), respectively), and these contrast-enhanced images were qualitatively and quantitatively evaluated for the differences of the biliary and renal excretion between normal and cirrhotic livers.

Results: The timing of biliary excretion of contrast agents in the cirrhotic liver was significantly slower than that in the normal liver (P<0.001). The degree of contrast enhancement in the common bile duct in the normal liver was significantly better than that in the cirrhotic liver (P=0.003). Contrast agents were demonstrated in the duodenum at 20 min HP in 8/44 (18%) cirrhotic liver while they were seen in 15/34 (44%) normal liver (P=0.013). The enhancement effects of renal medulla and portal vein at 20 min HP in the cirrhotic liver were significantly higher than those of normal liver (P=0.043 and P<0.001, respectively).

Conclusion: Biliary excretion of Gd-EOB-DPTA was impaired in cirrhotic livers in comparison with normal livers while renal excretion of Gd-EOB-DPTA was increased.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biliary Tract / pathology*
  • Contrast Media
  • Female
  • Gadolinium DTPA*
  • Humans
  • Image Enhancement / methods
  • Kidney / pathology*
  • Liver Cirrhosis / diagnosis*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA