Immunomodulating activity of ginsenoside Rg1 from Panax ginseng

Jpn J Pharmacol. 1990 Dec;54(4):447-54. doi: 10.1254/jjp.54.447.


The immunomodulatory activity of ginsenoside Rg1 from Panax ginseng was studied in mice using sheep red cells as the antigen. It was found that ginsenoside Rg1 at a dose of 10 mg/kg administered for three consecutive days before immunization increased the number of spleen plaque-forming cell, the titers of sera hemagglutinins as well as the number of antigen-reactive T-cells. Ginsenoside Rg1 also increased the number of T-helper cells with respect to the whole T-cell number and the splenocyte natural killer activity. Ginsenoside Rg1 induced an augmentation of the production of IL-1 by macrophages and exerted a direct mitogenic effect on microcultured thymus cells. Ginsenoside Rg1 also partly restored the impaired immune reactivity by cyclophosphamide treatment.

MeSH terms

  • Animals
  • Cell Count / drug effects
  • Erythrocytes / immunology
  • Ginsenosides*
  • Hemagglutinins / blood
  • Hemolytic Plaque Technique
  • Immunity, Cellular / drug effects
  • Lymphocyte Activation / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Saponins / immunology*
  • Saponins / isolation & purification
  • Sheep
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*


  • Ginsenosides
  • Hemagglutinins
  • Saponins
  • ginsenoside Rg1