Vitamin D serum levels and markers of asthma control in Italian children

J Pediatr. 2011 Mar;158(3):437-41. doi: 10.1016/j.jpeds.2010.08.043. Epub 2010 Sep 26.


Objective: To establish the relationship between vitamin D serum levels, pulmonary function, and asthma control in children.

Study design: We studied the relationship between 25-hydroxy cholecalciferol [25(OH)D] concentrations and baseline spirometry and levels of asthma control, assessed according to Global Initiative for Asthma guidelines and the Childhood Asthma Control Test, in 75 children with asthma (age range 5-11 years; 43 males) in a cross-sectional study carried out during the winter and early spring.

Results: Only 9.4% of our children had a sufficient serum 25(OH)D (at least 30 to 40 ng/mL). A significant positive correlation was found between forced vital capacity percent predicted and serum 25(OH)D (r = 0.25, P = .040). This was true also for forced expiratory volume in 1 second, even though it was not statistically significant (r = 0.16, P = .157). Subjects with well-controlled asthma had higher serum levels of 25(OH)D than children with partially controlled or non-controlled asthma, with values of (median [Q1; Q3]) 22.2 (16.3; 25.4), 17.8 (11.8; 22.1) and 18.1 (15.0; 18.5), respectively (P = .023). Furthermore, a positive correlation was found between 25(OH)D and the Childhood Asthma Control Test (r = 0.28; P = .011).

Conclusions: Our results indicate that hypovitaminosis D is frequent in children with asthma living in a Mediterranean country. In those children, lower levels of vitamin D are associated with reduced asthma control.

MeSH terms

  • Asthma / blood*
  • Asthma / epidemiology*
  • Biomarkers / blood
  • Calcifediol / blood*
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Female
  • Forced Expiratory Volume
  • Humans
  • Immunoglobulin E / blood
  • Italy / epidemiology
  • Male
  • Vital Capacity
  • Vitamin D Deficiency / epidemiology*


  • Biomarkers
  • Immunoglobulin E
  • Calcifediol