Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study

Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb;84(1-2):57-61. doi: 10.1016/j.plefa.2010.09.001. Epub 2010 Sep 25.

Abstract

F2-isoprostanes (F2-IsoP) are reportedly increased in dementia patients, and are considered a reliable biomarker of oxidation. However, few studies have examined the predictive value of peripheral F2-IsoP levels in non-demented older adults. This study assesses the association between plasma F2-IsoP and change in cognitive function in non-demented elderly over eight years. Plasma F2-IsoP was measured by gas chromatography-mass spectrometry in a biracial cohort of 726 elderly men and women. Digit Symbol Substitution test and the Modified Mini-Mental State Exam were administered over time. No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Cognition*
  • Cohort Studies
  • Dementia / metabolism
  • Dementia / psychology
  • Executive Function
  • F2-Isoprostanes / blood*
  • Female
  • Humans
  • Longitudinal Studies
  • Male

Substances

  • Biomarkers
  • F2-Isoprostanes