WT1 expression correlates with angiogenesis in endometrial cancer tissue

Anticancer Res. 2010 Aug;30(8):3187-92.


Background: No direct comparison has been made of the relationship between the expression of Wilms' tumor gene WT1 within tumor cells and angiogenesis in vivo.

Materials and methods: A series of 70 endometrial cancer patients who had undergone a curative resection was studied by immunohistochemistry to determine the correlation between WT1 expression, angiogenesis (proliferation of endothelial cell adhesion molecule-1, PECAM-1/CD31) and angiogenic growth factor (vascular endothelial growth factor, VEGF).

Results: A strong association was found between WT1 expression score and mean vascular density (p<0.001, n=70, ϱ=0.568). Immunohistochemistry of serial sections revealed that WT1 and VEGF were co-expressed in the same area of endometrial cancer tissue.

Conclusion: Tumor-produced WT1, which may regulate the expression of VEGF, is found to be associated with induction of angiogenesis in endometrial cancer.

MeSH terms

  • Adult
  • Aged
  • Endometrial Neoplasms / blood supply*
  • Endometrial Neoplasms / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neovascularization, Pathologic / metabolism*
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism
  • Vascular Endothelial Growth Factor A / metabolism
  • WT1 Proteins / metabolism*


  • Platelet Endothelial Cell Adhesion Molecule-1
  • Vascular Endothelial Growth Factor A
  • WT1 Proteins