T1 assessment of hip joint cartilage following intra-articular gadolinium injection: a pilot study

Magn Reson Med. 2010 Oct;64(4):1200-7. doi: 10.1002/mrm.22472.

Abstract

This pilot study defines the feasibility of cartilage assessment in symptomatic femoroacetabular impingement patients using intra-articular delayed gadolinium-enhanced MRI of cartilage (ia-dGEMRIC). Nine patients were scanned preliminary to study the contrast infiltration process into hip joint cartilage. Twenty-seven patients with symptomatic femoroacetabular impingement were subsequently scanned with intra-articular delayed gadolinium-enhanced MRI of cartilage. These T(1) findings were correlated to morphological findings. Zonal variations were studied. This pilot study demonstrates a significant difference between the pre- and postcontrast T(1) values (P < 0.001) remaining constant for 45 min. We noted higher mean T(1) values in morphologically normal-appearing cartilage than in damaged cartilage, which was statistically significant for all zones except the anterior-superior zone. Intraobserver (0.972) and interobserver correlation coefficients (0.933) were statistically significant. This study outlines the feasibility of intra-articular delayed gadolinium-enhanced MRI of cartilage for assessment of cartilage changes in patients with femoroacetabular impingement. It can also define the topographic extent and differing severities of cartilage damage.

MeSH terms

  • Adult
  • Aged
  • Cartilage Diseases / pathology*
  • Cartilage, Articular / pathology*
  • Contrast Media / administration & dosage
  • Feasibility Studies
  • Female
  • Gadolinium DTPA* / administration & dosage
  • Hip Joint / pathology*
  • Humans
  • Image Enhancement / methods*
  • Injections, Intra-Articular
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Pilot Projects
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Contrast Media
  • Gadolinium DTPA