Antioxidant activities of celery and parsley juices in rats treated with doxorubicin

Molecules. 2010 Sep 3;15(9):6193-204. doi: 10.3390/molecules15096193.


We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / pharmacology
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Apium / chemistry*
  • Cytochrome P-450 Enzyme System / analysis
  • Cytochrome P-450 Enzyme System / drug effects
  • Doxorubicin / pharmacology*
  • Drug Interactions
  • Liver / metabolism
  • Petroselinum / chemistry*
  • Plant Leaves / chemistry
  • Plant Roots / chemistry
  • Rats


  • Antibiotics, Antineoplastic
  • Antioxidants
  • Doxorubicin
  • Cytochrome P-450 Enzyme System