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Review
. 2010 Nov;6(11):679-88.
doi: 10.1038/nrneph.2010.116. Epub 2010 Sep 28.

Contrast-induced acute kidney injury and diabetic nephropathy

Andrew D Calvin  1 , Sanjay Misra, Axel Pflueger
Affiliations
Review

Contrast-induced acute kidney injury and diabetic nephropathy

Andrew D Calvin et al. Nat Rev Nephrol. 2010 Nov.

Abstract

Contrast-induced acute kidney injury (CIAKI) is a leading cause of iatrogenic renal failure. Multiple studies have shown that patients with diabetic nephropathy are at high risk of CIAKI. This Review presents an overview of the pathogenesis of CIAKI in patients with diabetic nephropathy and discusses the currently available and potential future strategies for CIAKI prevention.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The pathways potentially underlying the pathogenesis of CIAKI in patients with diabetes. Abbreviations: AKI, acute kidney injury; CIAKI, contrast-induced acute kidney injury; GFR, glomerular filtration rate; ROS, reactive oxygen species.
Figure 2
Figure 2
Both contrast media and diabetes affect dilation of the renal vasculature. Permission obtained from International Scientific Literature Inc. © Pflueger, A. et al. Med. Sci. Monit. 15, RA125–RA136 (2009).
See this image and copyright information in PMC

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