Abstract
Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Crystallography, X-Ray
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Molecular Sequence Data
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Peptides / chemical synthesis
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Peptides / chemistry
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Protein Structure, Tertiary
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Scorpion Venoms / chemical synthesis*
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Scorpion Venoms / chemistry
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Stereoisomerism
Substances
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Peptides
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Scorpion Venoms
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kaliotoxin